Rationale and design of the Karolinska‐Rennes (KaRen) prospective study of dyssynchrony in heart failure with preserved ejection fraction
Identifieur interne : 003906 ( Main/Exploration ); précédent : 003905; suivant : 003907Rationale and design of the Karolinska‐Rennes (KaRen) prospective study of dyssynchrony in heart failure with preserved ejection fraction
Auteurs : Erwan Donal [France] ; Lars H. Lund [Suède] ; Cecilia Linde [Suède] ; Magnus Edner [Suède] ; Stéphane Lafitte [France] ; Hans Persson [Suède] ; Fabrice Bauer [France] ; John Öhrvik [Suède] ; Pierre-Vladimir Ennezat [France] ; Camilla Hage [Suède] ; Ida Löfman [Suède] ; Yves Juilliere [France] ; Damien Logeart [France] ; Geneviève Derumeaux [France] ; Pascal Gueret [France] ; Jean-Claude Daubert [France]Source :
- European Journal of Heart Failure [ 1388-9842 ] ; 2009-02.
English descriptors
- Teeft :
- Acute presentation, American society, Baseline characteristics, Brain natriuretic peptide, Cardiac, Cardiac resynchronization therapy, Cardiol, Cardiology, Cardiopulmonary exercise testing, Charm investigators, Chronic heart failure, Clinical trials, Coll, Coll cardiol, Continuous variables, Core laboratory, Deceleration time, Diastolic, Diastolic dysfunction, Diastolic dyssynchrony, Diastolic function, Diastolic heart failure, Doppler, Doppler echocardiography, Dysfunction, Dyssynchrony, Echocardiographic, Echocardiographic examination, Echocardiography, Echocardiography dyssynchrony, Ejection, Ejection fraction, Electrical dyssynchrony, European heart rhythm association, European society, Exclusion criteria, Exercise echocardiography, Frame rate, Framingham criteria, Heart failure, Hfpef, Hfpef patients, Hfpef population, Hospitalization, Inclusion criteria, Index event, Index presentation, John sutton, Karen, Karen study, Karolinska university hospital, Lvef, Mechanical dyssynchrony, Overall mortality, Peak systolic velocities, Peak systolic velocity, Predictor, Prognosis, Prognostic, Prognostic impact, Prognostic implications, Prognostic value, Pulmonary time delays, Seattle heart failure model, Study design, Study endpoints, Systolic, Systolic dyssynchrony index, Systolic function, Systolic heart failure, Task force, Tissue synchronization imaging analysis, Ventricular, Ventricular ejection fraction, Ventricular function.
Abstract
Heart failure with preserved ejection fraction (HFPEF) is common but not well understood. Electrical dyssynchrony in systolic heart failure is harmful. Little is known about the prevalence and the prognostic impact of dyssynchrony in HFPEF.
We have designed a prospective, multicenter, international, observational study to characterize HFPEF and to determine whether electrical or mechanical dyssynchrony affects prognosis. Patients presenting with acute heart failure (HF) will be screened so as to identify 400 patients with HFPEF. Inclusion criteria will be: acute presentation with Framingham criteria for HF, left ventricular ejection fraction ≥ 45%, brain natriuretic peptide (BNP) > 100 pg/mL or NT‐proBNP > 300 pg/mL. Once stabilized, 4–8 weeks after the index presentation, patients will return and undergo questionnaires, serology, ECG, and Doppler echocardiography. Thereafter, patients will be followed for mortality and HF hospitalization every 6 months for at least 18 months. Sub‐studies will focus on echocardiographic changes from the acute presentation to the stable condition and on exercise echocardiography, cardiopulmonary exercise testing, and serological markers.
KaRen aims to characterize electrical and mechanical dyssynchrony and to assess its prognostic impact in HFPEF. The results might improve our understanding of HFPEF and generate answers to the question whether dyssynchrony could be a target for therapy in HFPEF.
Url:
DOI: 10.1093/eurjhf/hfn025
Affiliations:
- France, Suède
- Auvergne-Rhône-Alpes, Haute-Normandie, Rhône-Alpes, Région Bretagne, Région Normandie, Svealand, Île-de-France
- Créteil, Lyon, Paris, Rennes, Rouen, Stockholm
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Lund</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Linde, Cecilia" sort="Linde, Cecilia" uniqKey="Linde C" first="Cecilia" last="Linde">Cecilia Linde</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Edner, Magnus" sort="Edner, Magnus" uniqKey="Edner M" first="Magnus" last="Edner">Magnus Edner</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Danderyd University Hospital, 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sort="Bauer, Fabrice" uniqKey="Bauer F" first="Fabrice" last="Bauer">Fabrice Bauer</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, Charles Nicolle University Hospital, Rouen</wicri:regionArea><placeName><region type="region">Région Normandie</region><region type="old region">Haute-Normandie</region><settlement type="city">Rouen</settlement></placeName></affiliation></author><author><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Ennezat, Pierre Ladimir" sort="Ennezat, Pierre Ladimir" uniqKey="Ennezat P" first="Pierre-Vladimir" last="Ennezat">Pierre-Vladimir Ennezat</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, Hôpital Cardiologique, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Hage, Camilla" sort="Hage, Camilla" uniqKey="Hage C" first="Camilla" last="Hage">Camilla Hage</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Lofman, Ida" sort="Lofman, Ida" uniqKey="Lofman I" first="Ida" last="Löfman">Ida Löfman</name><affiliation wicri:level="3"><country xml:lang="fr">Suède</country><wicri:regionArea>Cardiology, Karolinska University Hospital, Stockholm</wicri:regionArea><placeName><settlement type="city">Stockholm</settlement><region nuts="2">Svealand</region></placeName></affiliation></author><author><name sortKey="Juilliere, Yves" sort="Juilliere, Yves" uniqKey="Juilliere Y" first="Yves" last="Juilliere">Yves Juilliere</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, CHU Nancy</wicri:regionArea><wicri:noRegion>CHU Nancy</wicri:noRegion><wicri:noRegion>CHU Nancy</wicri:noRegion></affiliation></author><author><name sortKey="Logeart, Damien" sort="Logeart, Damien" uniqKey="Logeart D" first="Damien" last="Logeart">Damien Logeart</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, Hôpital Lariboisière, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Derumeaux, Genevieve" sort="Derumeaux, Genevieve" uniqKey="Derumeaux G" first="Geneviève" last="Derumeaux">Geneviève Derumeaux</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, Hôpital Louis Pradel, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Gueret, Pascal" sort="Gueret, Pascal" uniqKey="Gueret P" first="Pascal" last="Gueret">Pascal Gueret</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, CHU Henri‐Mondor, Créteil</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Créteil</settlement></placeName></affiliation></author><author><name sortKey="Daubert, Jean Laude" sort="Daubert, Jean Laude" uniqKey="Daubert J" first="Jean-Claude" last="Daubert">Jean-Claude Daubert</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Cardiology, CHU Pontchaillou, 35033, Rennes</wicri:regionArea><placeName><region type="region" nuts="2">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Heart Failure</title><title level="j" type="alt">EUROPEAN JOURNAL OF HEART FAILURE</title><idno type="ISSN">1388-9842</idno><idno type="eISSN">1879-0844</idno><imprint><biblScope unit="vol">11</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="198">198</biblScope><biblScope unit="page" to="204">204</biblScope><biblScope unit="page-count">7</biblScope><date type="published" when="2009-02">2009-02</date></imprint><idno type="ISSN">1388-9842</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1388-9842</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute presentation</term><term>American society</term><term>Baseline characteristics</term><term>Brain natriuretic peptide</term><term>Cardiac</term><term>Cardiac resynchronization therapy</term><term>Cardiol</term><term>Cardiology</term><term>Cardiopulmonary exercise testing</term><term>Charm investigators</term><term>Chronic heart failure</term><term>Clinical trials</term><term>Coll</term><term>Coll cardiol</term><term>Continuous variables</term><term>Core laboratory</term><term>Deceleration time</term><term>Diastolic</term><term>Diastolic dysfunction</term><term>Diastolic dyssynchrony</term><term>Diastolic function</term><term>Diastolic heart failure</term><term>Doppler</term><term>Doppler echocardiography</term><term>Dysfunction</term><term>Dyssynchrony</term><term>Echocardiographic</term><term>Echocardiographic examination</term><term>Echocardiography</term><term>Echocardiography dyssynchrony</term><term>Ejection</term><term>Ejection fraction</term><term>Electrical dyssynchrony</term><term>European heart rhythm association</term><term>European society</term><term>Exclusion criteria</term><term>Exercise echocardiography</term><term>Frame rate</term><term>Framingham criteria</term><term>Heart failure</term><term>Hfpef</term><term>Hfpef patients</term><term>Hfpef population</term><term>Hospitalization</term><term>Inclusion criteria</term><term>Index event</term><term>Index presentation</term><term>John sutton</term><term>Karen</term><term>Karen study</term><term>Karolinska university hospital</term><term>Lvef</term><term>Mechanical dyssynchrony</term><term>Overall mortality</term><term>Peak systolic velocities</term><term>Peak systolic velocity</term><term>Predictor</term><term>Prognosis</term><term>Prognostic</term><term>Prognostic impact</term><term>Prognostic implications</term><term>Prognostic value</term><term>Pulmonary time delays</term><term>Seattle heart failure model</term><term>Study design</term><term>Study endpoints</term><term>Systolic</term><term>Systolic dyssynchrony index</term><term>Systolic function</term><term>Systolic heart failure</term><term>Task force</term><term>Tissue synchronization imaging analysis</term><term>Ventricular</term><term>Ventricular ejection fraction</term><term>Ventricular function</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Heart failure with preserved ejection fraction (HFPEF) is common but not well understood. Electrical dyssynchrony in systolic heart failure is harmful. Little is known about the prevalence and the prognostic impact of dyssynchrony in HFPEF.</div><div type="abstract">We have designed a prospective, multicenter, international, observational study to characterize HFPEF and to determine whether electrical or mechanical dyssynchrony affects prognosis. Patients presenting with acute heart failure (HF) will be screened so as to identify 400 patients with HFPEF. Inclusion criteria will be: acute presentation with Framingham criteria for HF, left ventricular ejection fraction ≥ 45%, brain natriuretic peptide (BNP) > 100 pg/mL or NT‐proBNP > 300 pg/mL. Once stabilized, 4–8 weeks after the index presentation, patients will return and undergo questionnaires, serology, ECG, and Doppler echocardiography. Thereafter, patients will be followed for mortality and HF hospitalization every 6 months for at least 18 months. Sub‐studies will focus on echocardiographic changes from the acute presentation to the stable condition and on exercise echocardiography, cardiopulmonary exercise testing, and serological markers.</div><div type="abstract">KaRen aims to characterize electrical and mechanical dyssynchrony and to assess its prognostic impact in HFPEF. The results might improve our understanding of HFPEF and generate answers to the question whether dyssynchrony could be a target for therapy in HFPEF.</div></front></TEI><affiliations><list><country><li>France</li><li>Suède</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Haute-Normandie</li><li>Rhône-Alpes</li><li>Région Bretagne</li><li>Région Normandie</li><li>Svealand</li><li>Île-de-France</li></region><settlement><li>Créteil</li><li>Lyon</li><li>Paris</li><li>Rennes</li><li>Rouen</li><li>Stockholm</li></settlement></list><tree><country name="France"><region name="Région Bretagne"><name sortKey="Donal, Erwan" sort="Donal, Erwan" uniqKey="Donal E" first="Erwan" last="Donal">Erwan Donal</name></region><name sortKey="Bauer, Fabrice" sort="Bauer, Fabrice" uniqKey="Bauer F" first="Fabrice" last="Bauer">Fabrice Bauer</name><name sortKey="Daubert, Jean Laude" sort="Daubert, Jean Laude" uniqKey="Daubert J" first="Jean-Claude" last="Daubert">Jean-Claude Daubert</name><name sortKey="Derumeaux, Genevieve" sort="Derumeaux, Genevieve" uniqKey="Derumeaux G" first="Geneviève" last="Derumeaux">Geneviève Derumeaux</name><name sortKey="Donal, Erwan" sort="Donal, Erwan" uniqKey="Donal E" first="Erwan" last="Donal">Erwan Donal</name><name sortKey="Ennezat, Pierre Ladimir" sort="Ennezat, Pierre Ladimir" uniqKey="Ennezat P" first="Pierre-Vladimir" last="Ennezat">Pierre-Vladimir Ennezat</name><name sortKey="Gueret, Pascal" sort="Gueret, Pascal" uniqKey="Gueret P" first="Pascal" last="Gueret">Pascal Gueret</name><name sortKey="Juilliere, Yves" sort="Juilliere, Yves" uniqKey="Juilliere Y" first="Yves" last="Juilliere">Yves Juilliere</name><name sortKey="Lafitte, Stephane" sort="Lafitte, Stephane" uniqKey="Lafitte S" first="Stéphane" last="Lafitte">Stéphane Lafitte</name><name sortKey="Logeart, Damien" sort="Logeart, Damien" uniqKey="Logeart D" first="Damien" last="Logeart">Damien Logeart</name></country><country name="Suède"><region name="Svealand"><name sortKey="Lund, Lars H" sort="Lund, Lars H" uniqKey="Lund L" first="Lars H." last="Lund">Lars H. Lund</name></region><name sortKey="Edner, Magnus" sort="Edner, Magnus" uniqKey="Edner M" first="Magnus" last="Edner">Magnus Edner</name><name sortKey="Hage, Camilla" sort="Hage, Camilla" uniqKey="Hage C" first="Camilla" last="Hage">Camilla Hage</name><name sortKey="Linde, Cecilia" sort="Linde, Cecilia" uniqKey="Linde C" first="Cecilia" last="Linde">Cecilia Linde</name><name sortKey="Lofman, Ida" sort="Lofman, Ida" uniqKey="Lofman I" first="Ida" last="Löfman">Ida Löfman</name><name sortKey="Ohrvik, John" sort="Ohrvik, John" uniqKey="Ohrvik J" first="John" last="Öhrvik">John Öhrvik</name><name sortKey="Persson, Hans" sort="Persson, Hans" uniqKey="Persson H" first="Hans" last="Persson">Hans Persson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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